Sjögren syndrome associated neuropathy

RecommendationsIVIG may be considered in severe, functionally disabling peripheral neuropathies associated with Sjögren syndrome or when other immunosuppressive therapies are contraindicated or ineffective.
Dose/Frequency of AdministrationInduction: 1 to 2 g/kg adjusted body weight divided over 1 to 5 days (maximum 1 g/kg/day).

Maintenance: 0.4 to 1 g/kg adjusted body weight divided over 1 to 5 days (maximum 1 g/kg/day), every 4 to 6 weeks.

Once the patient’s condition has stabilized, consider titrating the dose and/or the treatment interval to the lowest dose necessary to maintain clinical effectiveness.