Stiff Person Syndrome (Moersch–Woltman syndrome)

RecommendationsIVIG is recommended for treatment of patients with significant functional impairment, in consultation with a neurologist.
Dose/Frequency of AdministrationInduction: 2 g/kg adjusted body weight divided over 2 to 5 days.

Maintenance: 1 to 2 g/kg adjusted body weight divided over 1 to 5 days (maximum 1 g/kg/day), every 3 to 6 weeks.

Once the patient’s condition has stabilized, consider titrating the dose and/or the treatment interval to the lowest dose necessary to maintain clinical effectiveness