Lambert–Eaton Myasthenic Syndrome (LEMS)
Recommended Indications in which IG can be used
Order Number: N5-LEMS
| Recommendations | IVIG is recommended as an option for treatment. Maintenance therapy with IVIG may be used in patients who show objective evidence of clinical improvement with IVIG therapy but have incomplete response to oral maintenance therapies. |
| Dose/Frequency of Administration | Induction: 2 g/kg adjusted body weight divided over 2 to 5 days. Maintenance: 0.4 to 1 g/kg adjusted body weight, every 2 to 6 weeks. A maximum dose of 2 g/kg may be given in any 4-week period. Once the patient’s condition has stabilized, consider titrating the dose and/or the treatment interval to the lowest dose necessary to maintain clinical effectiveness. It is preferable to discontinue IVIG in favour of oral immunosuppressants, where possible. |