Bloody Easy Coagulation Simplified, third edition Handbook

This handbook provides practical information on coagulation. It is designed to enhance the knowledge of physicians, nurses and medical laboratory technologists about the basics of coagulation from laboratory testing to anticoagulant drugs and management of bleeding disorders.

Table of Content

1. The Basics of Coagulation and Clot Breakdown
2. Routine Coagulation Tests
   • Evaluating coagulation in the laboratory
   • Sample collection for coagulation testing
   • Prothrombin Time (PT)
   • International Normalized Ratio (INR)
   • Activated Partial Thromboplastin Time (APTT)
   • Mixing Study
   • Thrombin Time (TT)
   • Fibrinogen
   • D-Dimer
   • Anti-Xa assay
   • Summary
3. Anticoagulant Drugs
   • Unfractionated Heparin (UFH)
   • Low Molecular Weight Heparins (LMWHs)
   • Fondaparinux
   • Warfarin
   • Direct Thrombin Inhibitors (DTI)
   • Direct Factor Xa Inhibitors
4. Evaluating Abnormal Coagulation Tests
   • Prolonged PT / INR with normal APTT
   • Prolonged APTT with normal PT / INR
   • Prolonged APTT and PT / INR
   • Prolonged Thrombin Time (TT) with normal or prolonged APTT and PT / INR
5. Approach to the Evaluation of the Bleeding Patient
6. Diagnosis and Emergency Management of Common Bleeding Disorders
   • von Willebrand disease (VWD)
   • Disorders of platelet function
   • Hemophilia A and B (Factor VIII and IX deficiency)
   • Factor XI deficiency
   • Bleeding Disorder of Unknown Cause
   • Acquired Hemophilia A
7. Key References