Acute disseminated encephalomyelitis (ADEM)

Recommended Indications in which IG can be used

Order Number: N1-ADEM

RecommendationsIVIG is recommended for:
  • ADEM unresponsive to steroid therapy or where steroids are contraindicated.
  • Recurrent or multiphasic ADEM unresponsive to steroid therapy or where steroid therapy is contraindicated or has become intolerable.
For patients with relapsing ADEM, alternative diagnoses should be considered, including multiple sclerosis (MS), myelin oligodendrocyte glycoprotein antibody disorder (MOGAD), or neuromyelitis optica spectrum disorder (NMOSD), and other therapies may be offered as applicable.
Dose/Frequency of AdministrationInduction: 2 g/kg adjusted body weight divided over 2 to 5 days.

Maintenance (for recurrent or multiphasic ADEM only): 0.4 to 2 g/kg adjusted body weight every 4 to 6 weeks.

Once the patient’s condition has stabilized, consider titrating the dose and/or the treatment interval to the lowest dose necessary to maintain clinical effectiveness.