Varicella-zoster virus (VZV), prophylaxis, VZIG Unavailable

(see separate entry when VZV immune globulin is available)

RecommendationsONLY when VZV immune globulin is unavailable.

IVIG is a suitable alternative for varicella-susceptible immunocompromised patients when VZV immune globulin is unavailable within 96 hours after exposure
Dose/Frequency of AdministrationSingle dose of 0.4 g/kg adjusted body weight, as soon as possible. Ideally the dose should be given within 96 hours after exposure, but administration up to 10 days post-exposure may be helpful. Patients who have received IVIG within the prior 3 weeks are protected.