Fetal / Neonatal alloimmune thrombocytopenia (F/NAIT)

Recommended Indications in which IG can be used

Recommendations	Antenatal treatment: IVIG (with or without corticosteroids) is recommended as first line treatment for women with a previously affected infant
Dose/Frequency of Administration	Maternal dose based on the following risk stratification: Previous fetus with intracranial hemorrhage: Up to a total of 2 g/kg weekly starting as early as 12-16 weeks gestation. No previous fetus with intracranial hemorrhage: Up to 1g/kg weekly, starting as early as 20-26 weeks current gestation.

Recommendations	Newborn: IVIG is recommended as an adjunct to provision of platelets for infants with NAIT who have severe thrombocytopenia. Treatment should be administered in consultation with obstetrical medicine and transfusion medicine with expertise in F/NAIT.
Dose/Frequency of Administration	Infant dose: initial dose of 1 g/kg, reassess following initial dose.