Antiphospholipid syndrome – catastrophic

(See separate entry for Antiphospholipid Syndrome)

Recommended Indications in which IG can be used

Order Number: R1-ASC

RecommendationsIVIG is recommended for catastrophic antiphospholipid syndrome, characterized by widespread small vessel thrombosis leading to multiorgan failure.
 
Qualifying Criteria
All of the following criteria must be met:
  • Evidence of rapidly evolving thrombosis involving two or more organs.
  • Unequivocal laboratory evidence of antiphospholipid antibodies (lupus anticoagulant and/or anticardiolipin antibodies and/or beta 2 glycoprotein I antibodies).
  • Other causes of thrombotic microangiopathy are considered less likely.
Dose/Frequency of Administration2 g/kg adjusted body weight divided over 2 to 5 days. A single treatment is usually sufficient.

The potential prothrombotic effect of IVIG should be considered in this indication.