{"id":10510,"date":"2023-06-15T08:00:00","date_gmt":"2023-06-15T12:00:00","guid":{"rendered":"https:\/\/transfusionontario.org\/?p=10510"},"modified":"2024-07-17T11:17:52","modified_gmt":"2024-07-17T15:17:52","slug":"juin-2023","status":"publish","type":"post","link":"https:\/\/transfusionontario.org\/fr\/juin-2023\/","title":{"rendered":"Les plaquettes \u00e0 teneur r\u00e9duite en agents pathog\u00e8nes"},"content":{"rendered":"\n

Dr. Shuoyan Ning
Assistant Professor, Division of Hematology & Thromboembolism, Department of Medicine, McMaster University
Co-Director of Operations, Hamilton Regional Laboratory Medicine Program
Medical Officer, Canadian Blood Services
 
Dr. Michelle Zeller
Associate Professor, Division of Hematology & Thromboembolism, Department of Medicine, McMaster University
Co-Director of Operations, Hamilton Regional Laboratory Medicine Program
Medical Officer, Canadian Blood Services<\/em>
<\/p>\n\n\n\n

Pathogen-reduced platelets are a new platelet component manufactured by Canadian Blood Services. There are two types of pathogen-reduced platelets: pooled platelets psoralen-treated (PPPT) and apheresis platelets psoralen-treated (APPT). PPPT was first introduced in 2022 at select hospitals, and national rollout is currently underway. APPT is pending Health Canada approval. <\/p>\n\n\n\n

Le traitement INTERCEPT de Cerus est une technologie d\u2019inactivation des pathog\u00e8nes (TIP) qui sert \u00e0 la fabrication de plaquettes \u00e0 teneur r\u00e9duite en agents pathog\u00e8nes. Cette technologie recourt \u00e0 l\u2019amotosal\u00e8ne et au rayonnement UVA pour inactiver les virus, les bact\u00e9ries, les parasites protozoaires et les leucocytes. INTERCEPT est approuv\u00e9 dans l\u2019Union europ\u00e9enne depuis 2002 et a re\u00e7u l\u2019approbation de la FDA am\u00e9ricaine en 2014. Des essais cliniques et de vastes bases de donn\u00e9es d\u2019h\u00e9movigilance multinationales ont confirm\u00e9 l\u2019excellent profil d\u2019innocuit\u00e9 de cette technologie. <\/p>\n\n\n\n

La diminution importante des risques de transmission bact\u00e9rienne, les risques moindres d\u2019infections transfusionnelles non bact\u00e9riennes et la baisse des r\u00e9actions allergiques constituent les principaux avantages des plaquettes \u00e0 teneur r\u00e9duite en agents pathog\u00e8nes. Les globules blancs sont inactiv\u00e9s pendant l\u2019inactivation des agents pathog\u00e8nes, ce qui rend l\u2019irradiation inutile. En outre, aucune analyse bact\u00e9riologique n\u2019est requise, de sorte que les composants plaquettaires seront d\u00e9livr\u00e9s aux h\u00f4pitaux plus t\u00f4t dans leur dur\u00e9e de conservation. Le 24 avril dernier, la dur\u00e9e de conservation des PMTP a \u00e9t\u00e9 prolong\u00e9e, passant de 5 \u00e0 7 jours. Il y a des inconv\u00e9nients \u00e0 la transfusion de plaquettes \u00e0 teneur r\u00e9duite en agents pathog\u00e8nes, entre autres une l\u00e9g\u00e8re baisse de l\u2019augmentation de la num\u00e9ration plaquettaire apr\u00e8s la transfusion comparativement aux r\u00e9sultats obtenus avec des plaquettes non trait\u00e9es; aucune diff\u00e9rence n\u2019a \u00e9t\u00e9 constat\u00e9e dans les essais cliniques quant aux saignements. Il n\u2019y a pas de donn\u00e9es relatives aux transfusions intra-ut\u00e9rines, situation pour laquelle des plaquettes non trait\u00e9es seront \u00e9mises avec un pr\u00e9avis. <\/p>\n\n\n\n

Pour obtenir plus d\u2019information sur les plaquettes \u00e0 teneur r\u00e9duite en agents pathog\u00e8nes, veuillez consulter sur le portail \u00e9ducationnel \u2014 professionaleducation.blood.ca \u2014 de la Soci\u00e9t\u00e9 canadienne du sang les ressources p\u00e9dagogiques mises au point par une \u00e9quipe de ses experts. Ces ressources comprennent un chapitre complet sur les plaquettes r\u00e9duites en agents pathog\u00e8nes, des diaporamas \u00e0 t\u00e9l\u00e9charger ou \u00e0 \u00e9couter, des vid\u00e9os sur la fabrication des PMTP et des PAPT et un document de questions et r\u00e9ponses r\u00e9guli\u00e8rement mis \u00e0 jour. Toutes les ressources sont offertes en fran\u00e7ais et en anglais. Il y a aussi des r\u00e9unions en direct o\u00f9 poser des questions et obtenir des r\u00e9ponses; tout le monde qui veut y participer est bienvenu. <\/p>\n\n\n\n

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Dr. Shuoyan NingAssistant Professor, Division of Hematology & Thromboembolism, Department of Medicine, McMaster UniversityCo-Director of Operations, Hamilton Regional Laboratory Medicine ProgramMedical Officer, Canadian Blood Services Dr. Michelle ZellerAssociate Professor, Division of […]<\/p>\n","protected":false},"author":16,"featured_media":10426,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_tec_requires_first_save":true,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"_tribe_blocks_recurrence_rules":"","_tribe_blocks_recurrence_description":"","_tribe_blocks_recurrence_exclusions":"","footnotes":""},"categories":[138,137],"tags":[],"class_list":["post-10510","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bulletin","category-newsletter"],"acf":[],"_links":{"self":[{"href":"https:\/\/transfusionontario.org\/fr\/wp-json\/wp\/v2\/posts\/10510","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/transfusionontario.org\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/transfusionontario.org\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/transfusionontario.org\/fr\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/transfusionontario.org\/fr\/wp-json\/wp\/v2\/comments?post=10510"}],"version-history":[{"count":0,"href":"https:\/\/transfusionontario.org\/fr\/wp-json\/wp\/v2\/posts\/10510\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/transfusionontario.org\/fr\/wp-json\/wp\/v2\/media\/10426"}],"wp:attachment":[{"href":"https:\/\/transfusionontario.org\/fr\/wp-json\/wp\/v2\/media?parent=10510"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/transfusionontario.org\/fr\/wp-json\/wp\/v2\/categories?post=10510"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/transfusionontario.org\/fr\/wp-json\/wp\/v2\/tags?post=10510"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}