{"id":8727,"date":"2022-04-19T10:57:07","date_gmt":"2022-04-19T14:57:07","guid":{"rendered":"https:\/\/transfusionontario.org\/?p=8727"},"modified":"2024-07-25T09:47:19","modified_gmt":"2024-07-25T13:47:19","slug":"april-2022","status":"publish","type":"post","link":"https:\/\/transfusionontario.org\/en\/april-2022\/","title":{"rendered":"Transfusion Reaction Reporting"},"content":{"rendered":"\n

Donna Berta RN BScN, Clinical Project Coordinator \u2013 Nursing, ORBCoN<\/em><\/p>\n\n\n\n

Hemovigilance has been described as surveillance measures spanning the entire transfusion process from blood collection to blood recipient follow-up. Information on adverse transfusion effects is compiled to limit re-occurrence. The goal of reporting and evaluating adverse events is to improve transfusion safety.<\/p>\n\n\n\n

Canada\u2019s national hemovigilance system, Transfusion Transmitted Injuries Surveillance System (TTISS), was implemented by the Centre for Communicable Disease and Infection Control (CCDIC) of the Public Health Agency of Canada (PHAC) in 2001. Each province and territory report their transfusion reactions to TTISS. <\/p>\n\n\n\n

In Ontario, the Ministry of Health commissions the McMaster Centre for Transfusion Research of McMaster University to coordinate the province\u2019s TTISS actions (TTISS-ON). Participation is voluntary, but all Ontario hospitals have signed on to report moderate to severe transfusion reactions to blood components (red blood cells, platelets, plasma, cryoprecipitate) and plasma protein and related products (PPRP). <\/p>\n\n\n\n

Blood component serious or unexpected transfusion reactions (posing a significant risk to patient safety) and those pertaining to the safety of the blood itself must be reported to Health Canada\u2019s Canada Vigilance Program directly or via the manufacturer (Canadian Blood Services or H\u00e9ma-Qu\u00e9bec) in addition to TTISS-ON. Effective December 16, 2019 (as per Vanessa\u2019s Law<\/a>), PPRP serious adverse reactions must be reported directly to Health Canada\u2019s Canada Vigilance Program as well as to the manufacturer of the product. Refer to the TTISS-ON website for their interactive Ontario Guide for Reporting Transfusion Reactions<\/a> to identify the reporting requirements for each transfusion reaction.<\/p>\n\n\n\n

A sentinel site model (where 29 Ontario hospitals have committed to report all transfusion reactions [minor (febrile non-hemolytic, delayed serologic, and allergic) reactions in addition to major, moderate to severe, transfusion reactions] is an integral component of the TTISS-ON program. These 29 Ontario hospitals represent approximately 35% of all blood components transfused in Ontario. This sentinel site transfusion reaction data along with Canadian Blood Services (CBS) disposition data are used to calculate the Ontario incidence or frequency of transfusion reactions by type and by blood component. Sentinel site data for the 2020 calendar year are displayed in Figure 1 and 2 and Table 1. <\/p>\n\n\n\n

At annual hospital site visits, ORBCoN and CBS provide this data along with hospital specific data (based on transfusion reactions reported by that hospital) to highlight transfusion patient safety. Transfusion Medicine Services have reaction investigating and reporting accountabilities. Accordingly, transfusion prescribers and transfusionists are accountable to recognize and report transfusion reactions.  Hospital specific data reports (graphs and tables) generated from TTISS-ON and CBS data should be reviewed by Transfusion and Quality committees and shared with front line care providers to support hemovigilance. <\/p>\n\n\n\n

For more information about report generation resources, contact Joanne Duncan, TTISS-ON Coordinator (duncanj@mcmaster.ca<\/a>).<\/p>\n\n\n\n

Figure 1: <\/strong>2020, Sentinel Sites, Minor (febrile non-hemolytic, delayed serologic, and allergic) Reactions<\/p>\n\n\n\n

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Figure 2: <\/strong>2020, Sentinel Sites, Major (moderate to severe) Reactions<\/p>\n\n\n\n

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Table 1: <\/strong>2020, Sentinel Sites: Transfusion Reaction Type per Blood Component and Incidence of Major, Minor, Any Reaction per Blood Component<\/p>\n\n\n\n

Number of Units Transfused<\/strong><\/th>113,696<\/th>21,657<\/th>16,705<\/th>152,058<\/th><\/tr><\/thead>
<\/td>Red Blood Cells<\/strong><\/td>Platelets<\/strong><\/td>Plasma<\/strong><\/td>Total<\/strong><\/td><\/tr>
Transfusion Reaction Type<\/strong><\/td><\/td><\/td><\/td><\/td><\/tr>
Major<\/strong><\/td><\/td><\/td><\/td><\/td><\/tr>
Acute Hemolytic<\/td>1<\/td><\/td><\/td>1<\/td><\/tr>
Bacterial Infection<\/td><\/td>2<\/td><\/td>2<\/td><\/tr>
Delayed Hemolytic<\/td>15<\/td><\/td><\/td>15<\/td><\/tr>
Hypotensive<\/td>4<\/td>1<\/td><\/td>5<\/td><\/tr>
Other nonspecific pain<\/td>2<\/td><\/td><\/td>2<\/td><\/tr>
Other results of Investigation<\/td>8<\/td>5<\/td><\/td>13<\/td><\/tr>
Possible TRALI<\/td>1<\/td>1<\/td>1<\/td>3<\/td><\/tr>
Severe Allergic\/Anaphylactic\/Anaphylactoid<\/td>2<\/td>7<\/td>1<\/td>10<\/td><\/tr>
TACO<\/td>34<\/td>6<\/td>1<\/td>41<\/td><\/tr>
TAD<\/td><\/td>1<\/td>1<\/td>2<\/td><\/tr>
TRALI<\/td>1<\/td><\/td><\/td>1<\/td><\/tr>
Minor<\/strong><\/td><\/td><\/td><\/td><\/td><\/tr>
Delayed Serological<\/td>105<\/td>1<\/td><\/td>106<\/td><\/tr>
Febrile Non-Hemolytic<\/td>165<\/td>55<\/td>2<\/td>222<\/td><\/tr>
Minor Allergic<\/td>31<\/td>91<\/td>14<\/td>136<\/td><\/tr>
Total<\/strong><\/td>369<\/td>170<\/td>20<\/td>559<\/td><\/tr>
Incidence of Major Reaction<\/td>1 in 1,672<\/td>1 in 941<\/td>1 in 4,176<\/td>1 in 1,600<\/td><\/tr>
Incidence of Minor Reaction<\/td>1 in 377<\/td>1 in 147<\/td>1 in 1,044<\/td>1 in 328<\/td><\/tr>
Incidence of Any Reaction<\/td>1 in 308<\/td>1 in 127<\/td>1 in 835<\/td>1 in 272<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

Acknowledgement: 
<\/strong>Ontario Transfusion Transmitted Injuries Surveillance System (TTISS-ON) is gratefully acknowledged for the data provided.<\/p>\n\n\n\n

References:
<\/strong>Canadian Blood Services (CBS) A guide to reporting adverse transfusion reactions [Internet]. [Ottawa], CBS; 2020 [cited 2022 Mar 7]. Available from: 
https:\/\/professionaleducation.blood.ca\/en\/guide-reporting-adverse-transfusion-reactions<\/a><\/p>\n\n\n\n

International Society of Blood Transfusion (ISBT). Haemovigilance [Internet]. [Amsterdam, the Netherlands], ISBT; 2022 [cited 2022 Mar 7]. Available from: 
https:\/\/www.isbtweb.org\/isbt-working-parties\/haemovigilance.html<\/a><\/p>\n\n\n\n

Ontario Transfusion Transmitted Injuries Surveillance System (TTISS-ON). Report an adverse reaction [Internet]. [Hamilton], TTISS-ON; 2022 [cited 2022 Mar 7]. Available from: https:\/\/ttiss.mcmaster.ca\/?page_id=65<\/a><\/p>\n\n\n\n

Celebrating National Medical Laboratory Week <\/h3>\n\n\n
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Medical laboratories are at the centre of healthcare! Although you might not see them, #LabISEssential. On behalf of ORBCoN Happy National Medical Laboratory Week to all medical laboratory professionals for everything you do!<\/p>\n\n\n\n

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Click Here To Learn More<\/a><\/div>\n<\/div>\n\n\n\n

Register: CSTM 2022 Annual Conference<\/h3>\n\n\n
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Click Here To Register<\/a><\/div>\n<\/div>\n\n\n\n

Register: Perinatal Consensus Conference<\/h3>\n\n\n
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Click Here To Register<\/a><\/div>\n<\/div>\n\n\n\n

Featured Resource: IVIG Infusion Guide<\/h3>\n\n\n
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Click Here To Find More<\/a><\/div>\n<\/div>\n\n\n\n

Coming Soon: Transfusion Medicine Education Web Conference Archive Video<\/h3>\n\n\n\n

The 17th annual Transfusion Medicine Education Web Conference was held April 8th 2022. This event showcased dealing with different transfusion requirements for different types of patients with a massive bleed. If you missed the event it will be archived on the Transfusion Ontario website for viewing. Watch for it on transfusionontario.org in the coming week. We would like to extend our thanks to the organizers and the speakers for another great symposium. See you all next year!<\/p>\n\n\n

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Upcoming Event: University of Toronto Transfusion Medicine Rounds<\/h3>\n\n\n
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April 28th, 2022 @ 12:00 pm \u2013 1:00 pm
<\/strong>Transfusion Related Acute Lung Injury (TRALI), presented by Dr. Alexander Vlaar  <\/p>\n\n\n\n

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Click to Find More<\/a><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Donna Berta RN BScN, Clinical Project Coordinator \u2013 Nursing, ORBCoN Hemovigilance has been described as surveillance measures spanning the entire transfusion process from blood collection to blood recipient follow-up. Information […]<\/p>\n","protected":false},"author":1,"featured_media":8568,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"footnotes":""},"categories":[137],"tags":[],"class_list":["post-8727","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-newsletter"],"acf":[],"_links":{"self":[{"href":"https:\/\/transfusionontario.org\/en\/wp-json\/wp\/v2\/posts\/8727","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/transfusionontario.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/transfusionontario.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/transfusionontario.org\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/transfusionontario.org\/en\/wp-json\/wp\/v2\/comments?post=8727"}],"version-history":[{"count":0,"href":"https:\/\/transfusionontario.org\/en\/wp-json\/wp\/v2\/posts\/8727\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/transfusionontario.org\/en\/wp-json\/wp\/v2\/media\/8568"}],"wp:attachment":[{"href":"https:\/\/transfusionontario.org\/en\/wp-json\/wp\/v2\/media?parent=8727"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/transfusionontario.org\/en\/wp-json\/wp\/v2\/categories?post=8727"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/transfusionontario.org\/en\/wp-json\/wp\/v2\/tags?post=8727"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}