{"id":12701,"date":"2025-01-27T14:27:29","date_gmt":"2025-01-27T19:27:29","guid":{"rendered":"https:\/\/transfusionontario.org\/?p=12701"},"modified":"2025-01-27T15:03:22","modified_gmt":"2025-01-27T20:03:22","slug":"community-acquired-respiratory-virus-upper-respiratory-tract-infection-high-risk-patients-igum","status":"publish","type":"post","link":"https:\/\/transfusionontario.org\/en\/community-acquired-respiratory-virus-upper-respiratory-tract-infection-high-risk-patients-igum\/","title":{"rendered":"Community-acquired respiratory virus (CARV), upper respiratory tract infection (URTI) in high-risk patients"},"content":{"rendered":"\n

Recommended Indications in which IG can be used<\/strong><\/h2>\n\n\n\n

Order Number: T1-CARV\/URTI<\/strong><\/span><\/h3>\n\n\n\n
Recommendations<\/strong><\/td>Proven respiratory syncytial virus (RSV) in high-risk patients*<\/strong>\u00a0
IG may be used to prevent progression to lower respiratory tract infection.
*Note<\/strong> The term \u201chigh-risk patient\u201d signifies:
  • Lung transplant recipients. <\/li>
  • Allogeneic HSCT recipients with at least one of the following: <\/li>
    • hypogammaglobulinemia, defined as an IgG level less than the lower limit of normal or <4 g\/L <\/li>
    • absolute lymphocyte count <0.5 x 109\/L <\/li>
    • CD4 T-cell count <0.2 x 109\/L <\/li>
    • 6 months post alemtuzumab, anti-thymocyte globulin, rituximab therapy, or other B-cell depleting therapy (e.g., blinatumomab) <\/li>
    • steroid refractory or steroid dependent acute graft-versus-host disease<\/li>
    • moderate to severe chronic graft-versus-host disease; or <\/li>
    • Prolonged use of systemic corticosteroids at a dose of at least 0.5 mg prednisone equivalents\/kg\/day for at least 1 week.<\/li><\/ul>
    • Recipients of chimeric antigen receptor T-cells (CAR-T) for relapsed or refractory acute leukemia, multiple myeloma, chronic lymphocytic leukemia, or non-Hodgkin lymphoma (or other indication) with ongoing evidence of B-cell lymphopenia who are not receiving regular immunoglobulin replacement.<\/li><\/ul><\/td><\/tr>
Dose\/Frequency of Administration<\/strong><\/td>Single dose of 1 g\/kg adjusted body weight, with IgG level reassessed weekly. Consider retreatment if IgG level remains below the lower limit of normal.<\/a><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Recommended Indications in which IG can be used<\/p>\n

Order Number: T1-CARV\/URTI<\/p>\n","protected":false},"author":16,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"footnotes":""},"categories":[400],"tags":[],"class_list":["post-12701","post","type-post","status-publish","format-standard","hentry","category-transplant-indications"],"acf":[],"_links":{"self":[{"href":"https:\/\/transfusionontario.org\/en\/wp-json\/wp\/v2\/posts\/12701","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/transfusionontario.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/transfusionontario.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/transfusionontario.org\/en\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/transfusionontario.org\/en\/wp-json\/wp\/v2\/comments?post=12701"}],"version-history":[{"count":0,"href":"https:\/\/transfusionontario.org\/en\/wp-json\/wp\/v2\/posts\/12701\/revisions"}],"wp:attachment":[{"href":"https:\/\/transfusionontario.org\/en\/wp-json\/wp\/v2\/media?parent=12701"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/transfusionontario.org\/en\/wp-json\/wp\/v2\/categories?post=12701"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/transfusionontario.org\/en\/wp-json\/wp\/v2\/tags?post=12701"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}