{"id":12654,"date":"2025-01-27T14:36:00","date_gmt":"2025-01-27T19:36:00","guid":{"rendered":"https:\/\/transfusionontario.org\/?p=12654"},"modified":"2025-01-27T15:46:09","modified_gmt":"2025-01-27T20:46:09","slug":"demyelinating-neuropathy-associated-with-igm-paraproteinemia-igum","status":"publish","type":"post","link":"https:\/\/transfusionontario.org\/en\/demyelinating-neuropathy-associated-with-igm-paraproteinemia-igum\/","title":{"rendered":"Neuropathy associated with IgM paraproteinemia"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">(See separate entry for <a href=\"https:\/\/transfusionontario.org\/en\/axonal-neuropathy-associated-with-igm-paraproteinemia-igum\">Axonal neuropathy associated with IgM paraproteinemia<\/a>)<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-text-color has-link-color has-medium-font-size wp-elements-036f609a813ebf7c494f7208c56cbbdc\" style=\"color:#477d6c\"><strong>Recommended Indications in which IG can be used<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading has-black-color has-text-color has-background has-link-color has-small-font-size wp-elements-5c24b8d5cad4a13363a653d514d306e0\" style=\"background-color:#a5cbbf\"><strong>Order Number: N10-NAIgMP<\/strong><span style=\"font-size: medium; font-weight: 400; white-space-collapse: collapse;\"><\/span><\/h3>\n\n\n\n<figure class=\"wp-block-table is-style-regular\"><table><tbody><tr><td><strong>Recommendations<\/strong><\/td><td><strong>Demyelinating neuropathy associated with IgM paraproteinemia, <u>without<\/u> anti-MAG antibodies<\/strong><br>IVIG is recommended for neuropathy associated with IgM, with clinical and electrophysiological features consistent with CIDP, in the absence of anti-MAG antibodies.<span style=\"font-size: medium; white-space-collapse: collapse;\"><\/span><\/td><\/tr><tr><td><strong>Dose\/Frequency of Administration<\/strong><\/td><td>2 g\/kg adjusted body weight divided over 2 to 5 days, every 4 weeks.<br><br>IVIG should be administered for 3 to 6 months to assess efficacy. Some patients do not show a definitive sustained response until they have undergone up to 6 treatment cycles.<br><br>Once the patient\u2019s condition has stabilized, consider titrating the dose and\/or the treatment interval to the lowest dose necessary to maintain clinical effectiveness.<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Recommended Indications in which IG can be used<\/p>\n<p>Order Number: N10-NAIgMP<\/p>\n","protected":false},"author":16,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":true,"_tec_requires_first_save":true,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"_tribe_blocks_recurrence_rules":"","_tribe_blocks_recurrence_description":"","_tribe_blocks_recurrence_exclusions":"","footnotes":""},"categories":[398],"tags":[],"class_list":["post-12654","post","type-post","status-publish","format-standard","hentry","category-neurology-indications"],"acf":[],"_links":{"self":[{"href":"https:\/\/transfusionontario.org\/en\/wp-json\/wp\/v2\/posts\/12654","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/transfusionontario.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/transfusionontario.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/transfusionontario.org\/en\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/transfusionontario.org\/en\/wp-json\/wp\/v2\/comments?post=12654"}],"version-history":[{"count":0,"href":"https:\/\/transfusionontario.org\/en\/wp-json\/wp\/v2\/posts\/12654\/revisions"}],"wp:attachment":[{"href":"https:\/\/transfusionontario.org\/en\/wp-json\/wp\/v2\/media?parent=12654"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/transfusionontario.org\/en\/wp-json\/wp\/v2\/categories?post=12654"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/transfusionontario.org\/en\/wp-json\/wp\/v2\/tags?post=12654"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}