A. Transfuse maternal platelets to the baby. The rationale is that this thrombocytopenia is likely due to maternal antibodies to a paternal platelet antigen on the infant’s platelets. The quickest reliable source of compatible platelets is the mother, whose platelets will not be affected by antibody to the antigen derived from the fathers genetic constitution. Maternal platelets must be irradiated prior to transfusion, to prevent graft-vs.-host disease. In the event that maternal platelets are not a practical option, platelets negative for the antigen to which the mother is sensitised can be transfused, if available (e.g. HPA-1a antigen negative). In an emergency situation, random donor platelets may be used, while awaiting the delivery of antigen negative platelets.
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